Sunday, 24 December 2023
Eat Carrots and Prevent Cancer: Unveiling the Superfood's Hidden Powers
Saturday, 18 March 2023
Can Particles in Dairy and Beef Cause Cancer and MS?
Researchers from the German Cancer Research Center(DKFZ) suspect that such zoonoses are possibly widespread and are therefore recommending that infants not be given dairy products until they are at least age 1 year. However, in two joint statements, the German Federal Institute for Risk Assessment (BfR) and the Max Rubner Institute (MRI) have rejected such theories.
In 2008, Harald zur Hausen, MD, DSc, received the Nobel Prize in Medicine for his discovery that human papillomaviruses cause cervical cancer. His starting point was the observation that sexually abstinent women, such as nuns, rarely develop this cancer. So it was possible to draw the conclusion that pathogens are transmitted during sexual intercourse, explain zur Hausen and his wife Ethel-Michele de Villiers, PhD, both of DKFZ Heidelberg.
Papillomaviruses, as well as human herpes and Epstein-Barr viruses (EBV), polyomaviruses, and retroviruses, cause cancer in a direct way: by inserting their genes into the DNA of human cells. With a latency of a few years to a few decades, the proteins formed through expression stimulate malignant growth by altering the regulating host gene.
Acid Radicals
However, viruses — just like bacteria and parasites — can also indirectly trigger cancer. One mechanism for this triggering is the disruption of immune defenses, as shown by the sometimes drastically increased tumor incidence with AIDS or with immunosuppressants after transplants. Chronic inflammation is a second mechanism that generates acid radicals and thereby causes random mutations in replicating cells. Examples include stomach cancer caused by Helicobacter pyloriand liver cancer caused by Schistosoma, liver fluke, and hepatitis B and C viruses.
According to de Villiers and zur Hausen, there are good reasons to believe that other pathogens could cause chronic inflammation and thereby lead to cancer. Epidemiologic data suggest that dairy and meat products from European cows (Bos taurus) are a potential source. This is because colon cancer and breast cancer commonly occur in places where these foods are heavily consumed (ie, in North America, Argentina, Europe, and Australia). In contrast, the rate is low in India, where cows are revered as holy animals. Also noteworthy is that women with a lactose intolerance rarely develop breast cancer.
Viral Progeny
In fact, the researchers found single-stranded DNA rings that originated in viruses, which they named bovine meat and milk factors (BMMF), in the intestines of patients with colon cancer. They reported, "This new class of pathogen deserves, in our opinion at least, to become the focus of cancer development and further chronic diseases." They also detected elevated levels of acid radicals in these areas (ie, oxidative stress), which is typical for chronic inflammation.
The researchers assume that infants, whose immune system is not yet fully matured, ingest the BMMF as soon as they have dairy. Therefore, there is no need for adults to avoid dairy or beef because everyone is infected anyway, said zur Hausen in a speech.
'Breast Milk Is Healthy'
De Villiers and zur Hausen outlined more evidence of cancer-triggering pathogens. Mothers who have breastfed are less likely, especially after multiple pregnancies, to develop tumors in various organs or to have from MS and type 2 diabetes. The authors attribute the protective effect to oligosaccharides in breast milk, which begin to be formed midway through the pregnancy. They bind to lectin receptors and, in so doing, mask the terminal molecule onto which the viruses need to dock. As a result, their port of entry into the cells is blocked.
The oligosaccharides also protect the baby against life-threatening infections by blocking access by rotaviruses and noroviruses. In this way, especially if breastfeeding lasts a long time — around 1 year — the period of incomplete immunocompetence is bridged.
Colon Cancer
To date, it has been assumed that around 20% of all cancerous diseases globally are caused by infections, said the researchers. But if the suspected BMMF cases are included, this figure rises to 50%, even to around 80%, for colon cancer. If the suspicion is confirmed, the consequences for prevention and therapy would be significant.
The voice of a Nobel prize winner undoubtedly carries weight, but at the time, zur Hausen still had to convince a host of skeptics with his discovery that a viral infection is a major cause of cervical cancer. Nonetheless, some indicators suggest that he and his wife have found a dead end this time.
Institutional Skepticism
When his working group made the results public in February 2019, the DKFZ felt the need to give an all-clear signal in response to alarmed press reports. There is no reason to see dairy and meat consumption as something negative. Similarly, in their first joint statement, the BfR and the MRI judged the data to be insufficient and called for further studies. Multiple research teams began to focus on BMMF as a result. In what foods can they be found? Are they more common in patients with cancer than in healthy people? Are they infectious? Do they cause inflammation and cancer?
The findings presented in a second statement by the BfR and MRI at the end of November 2022 contradicted the claims made by the DKFZ scientists across the board. In no way do BMMF represent new pathogens. They are variants of already known DNA sequences. In addition, they are present in numerous animal-based and plant-based foods, including pork, fish, fruit, vegetables, and nuts.
BMMF do not possess the ability to infect human cells, the institutes said. The proof that they are damaging to one's health was also absent. It is true that the incidence of intestinal tumors correlates positively with the consumption of red and processed meat — which in no way signifies causality — but dairy products are linked to a reduced risk. On the other hand, breast cancer cannot be associated with the consumption of beef or dairy.
Therefore, both institutes recommend continuing to use these products as supplementary diet for infants due to their micronutrients. They further stated that the products are safe for people of all ages.
Association With MS?
Unperturbed, de Villiers and zur Hausen went one step further in their current article. They posited that MS is also associated with the consumption of dairy products and beef. Here too geographic distribution prompted the idea to look for BMMF in the brain lesions of patients with MS. The researchers isolated ring-shaped DNA molecules that proved to be closely related to BMMF from dairy and cattle blood. "The result was electrifying for us."However, there are several other factors to consider, such as vitamin D3 deficiency. This is because the incidence of MS decreases the further you travel from the poles toward the equator (ie, as solar radiation increases). Also, the EBV clearly plays a role because patients with MS display increased titers of EBV antibodies. One study also showed that people in Antarctica excreted reactivated EBV in their saliva during winter and that vitamin D3 stopped the viral secretion.
Under these conditions, the researchers hypothesized that MS is caused by a double infection of brain cells by EBV and BMMF. EBV is reactivated by a lack of vitamin D3, and the BMMF multiply and are eventually converted into proteins. A focal immunoreaction causes the Schwann cells and oligodendrocytes to malfunction, which leads to the destruction of the myelin sheaths around the nerve fibers.
Wednesday, 22 January 2020
SCIENTISTS DISCOVER IMMUNE CELL THAT KILLS MOST CANCERS
The treatment leverages T-cells, a type of white blood cell that helps our bodies’ immune systems by scanning for and killing abnormal cells. For background, scientists have recently started harnessing that ability in the fight against cancer through CAR-T, which involves removing T-cells from a patient’s blood and genetically engineering them to seek out and destroy cancer cells.
While promising, CAR-T has limitations. It’s patient-specific, works against only a small number of cancers, and isn’t effective against solid tumors, which comprise the majority of cancers.
On Monday, researchers from Cardiff University published a new study in the journal Nature Immunology detailing their discovery of a T-Cell equipped with a new type of T-cell receptor (TCR) that recognizes a molecule called MR1.
This molecule appears on the surface of many types of cancer cells as well as healthy cells, but T-cells equipped with this TCR know to kill only cancer cells.
And not just the kind linked to a single type of cancer, either. When the Cardiff researchers equipped T-cells in lab tests with this new TCR, the cells killed lung, skin, blood, colon, breast, bone, prostate, ovarian, kidney and cervical cancer cells — all while ignoring healthy cells.
In another lab test, the team modified the T-cells of melanoma patients to express the newly discovered TCR and found that the cells could then target and destroy both that patient’s own cancer cells and the cancer cells of other patients.
The team has yet to test the modified T-cells in actual cancer patients, but when tested in mice injected with human cancers, the cells recognized the MR1 molecule and exhibited “encouraging” cancer-killing abilities, according to a Cardiff press release.
The Cardiff scientists now plan to conduct additional tests. If those goes as hoped, the treatment could be ready for patients within a few years, researcher Andrew Sewell said in the press release.
“Cancer-targeting via MR1-restricted T-cells is an exciting new frontier,” he added. “It raises the prospect of a ‘one-size-fits-all’ cancer treatment; a single type of T-cell that could be capable of destroying many different types of cancers across the population. Previously nobody believed this could be possible.”
Saturday, 19 October 2019
5G makes your internet fast but may double the chance of getting cancer!!
As 5G cellular network tech looms, conventional wisdom dictates that cell phone radiation is more or less safe or less safe for humans.
But writing for the widely respected magazine Scientific American, University of California, Berkeley, public health researcher Joel Moskowitz argues that we don’t yet understand the risks — and that more study is necessary before we roll out 5G infrastructure.
Moskowitz’s main concern: there just isn’t any research on the health effects of 5G. But he also points to a swathe of studies a swathe of studies that suggest that the existing standards 2G and 3G are more dangerous than generally believed.
“Meanwhile, we are seeing increases in certain types of head and neck tumors in tumor registries, which may be at least partially attributable to the proliferation of cell phone radiation,” he wrote in SciAm. “These increases are consistent with results from case-control studies of tumor risk in heavy cell phone users.”
It’s hard enough to quantify the health effects of things that have already been deployed, nevermind an upcoming technology. But in SciAm, Moskowitz argues that regulators should listen to the 250 doctors and scientists who recently signed the 5G appeal, a petition for a moratorium on public rollout of the tech until the health implications are better understood.
“As a society, should we invest hundreds of billions of dollars deploying 5G, a cellular technology that requires the installation of 800,000 or more new cell antenna sites in the U.S. close to where we live, work and play?” he asked. “Instead, we should support the recommendations of the 250 scientists and medical doctors who signed the 5G Appeal that calls for an immediate moratorium on the deployment of 5G and demand that our government fund the research needed to adopt biologically based exposure limits that protect our health and safety.”
Friday, 19 April 2019
Paedophilia Symptoms can be caused by Brain Tumours in the right orbitofrontal cortex
Monday, 9 October 2017
Cure for Cancer! The Executioner Protein
Scientists have discovered a way to use the "executioner protein" BAX to induce apoptosis in cancer cells while leaving healthy cells intact. The treatment has so far been applied only to acute myeloid leukemia (AML) cells but may have broader uses.
KILLING CANCER WITH APOPTOSIS
Albert Einstein College of Medicine scientists have induced cancer cells to commit suicide with a new compound that leaves healthy cells untouched. They deployed their novel treatment approach against acute myeloid leukemia (AML) cells, which kill more than 10,000 Americans, and makes up about one-third of all new cases of leukemia, each year. Patients survive AML at a rate of only about 30 percent, making effective new treatments a hot commodity. And although the team has only tested the treatment on AML, it could have the potential to successfully attack other varieties of cancer cells.
“We’re hopeful that the targeted compounds we’re developing will prove more effective than current anti-cancer therapies by directly causing cancer cells to self-destruct,” associate professor of medicine and biochemistry and senior author Evripidis Gavathiotis said in a press release. “Ideally, our compounds would be combined with other treatments to kill cancer cells faster and more efficiently—and with fewer adverse effects, which are an all-too-common problem with standard chemotherapies.”
KILLING CANCER WITH APOPTOSIS
Albert Einstein College of Medicine scientists have induced cancer cells to commit suicide with a new compound that leaves healthy cells untouched. They deployed their novel treatment approach against acute myeloid leukemia (AML) cells, which kill more than 10,000 Americans, and makes up about one-third of all new cases of leukemia, each year. Patients survive AML at a rate of only about 30 percent, making effective new treatments a hot commodity. And although the team has only tested the treatment on AML, it could have the potential to successfully attack other varieties of cancer cells.
“We’re hopeful that the targeted compounds we’re developing will prove more effective than current anti-cancer therapies by directly causing cancer cells to self-destruct,” associate professor of medicine and biochemistry and senior author Evripidis Gavathiotis said in a press release. “Ideally, our compounds would be combined with other treatments to kill cancer cells faster and more efficiently—and with fewer adverse effects, which are an all-too-common problem with standard chemotherapies.”
The new compound fights cancer by triggering apoptosis: a natural process the body uses to get rid of malfunctioning and unwanted cells. Apoptosis also takes place during embryonic development: trimming excess tissue from the growing embryo, for example. While certain existing chemotherapy drugs induce apoptosis indirectly by damaging the DNA in cancer cells, this treatment directly triggers the process intentionally by activating BAX, the “executioner protein.”
THE EXECUTIONER PROTEIN
Pro-apoptopic proteins activate BAX in cells. Once BAX molecules go to work, they find the mitochondria of target cells and drill lethal holes into them, scuttling their ability to produce energy. Cancer cells resist BAX and this process by producing large quantities of “anti-apoptotic” proteins that suppress BAX and even the proteins that activate it. The process discovered by these researchers wakes BAX up again and sends it back to work.
“Our novel compound revives suppressed BAX molecules in cancer cells by binding with high affinity to BAX’s activation site,” Dr. Gavathiotis said in the release. “BAX can then swing into action, killing cancer cells while leaving healthy cells unscathed.”
In 2008, Dr. Gavathiotis was part of the team that first described the BAX’s activation site’s shape and structure. Since that time, he has been searching for small molecules to activate BAX and produce sufficient activity to overpower the natural resistance cancer cells mount to apoptosis. His team screened more than one million compounds and narrowed the field to 500, many of them synthesized by the team, and then evaluated them. These results reveal the outcome of that search.
BTSA1 (short for BAX Trigger Site Activator 1) was the best compound against several different human AML cell lines, including those found in high-risk AML patients. BTSA1 was also able to induce apoptosis in AML cells without affecting healthy stem cells. In AML mice treated with the compound, there was a significantly longer survival rate: 43 percent of the control group was alive and AML-free after 60 days. The BTSA1-treated mice also exhibited no signs of toxicity.
“BTSA1 activates BAX and causes apoptosis in AML cells while sparing healthy cells and tissues—probably because the cancer cells are primed for apoptosis,” Dr. Gavathiotis said in the release. Next the team plans to test BTSA1 on other types of cancer using animal models.
Tuesday, 2 May 2017
Can WiFi cause cancer?
So lets review
We do have a mechanism to explain the association between ionizing radiation and tumour induction, but out of millions of people who have received radiation therapy to their brain, only 73 radiation induced gliomas have been reported in the world's literature.
For radiation induced neoplasms in general, epidemiologic studies can show an increase in the likelihood of tumours with only a few thousand people over a time period less than ten years
Now lets get down to why this sort of irrational belief takes hold and, among other things, prompts five questions on this subject (at least that I have seen) in the time that I have been reading Quora (less than two months).